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Treating Genetic Diseases Through Precision Medicine Revolution

Precision medicine revolution is gaining traction in the field of medicine as it introduces new potentials in preventing and curing genetic diseases. Cancer and heart diseases are the leading causes of death in the United States, and conventional medical treatments are not always effective. Advancements in precision medicine revolution could significantly mitigate the staggering number of deaths due to chronic illnesses. The scientific community cannot address this alone and needs support from private and public partnerships to succeed.

What is Precision Medicine?

Current treatments for chronic diseases have a one-size-fits-all approach. This means doctors sometimes have blanket treatments and prescriptions for illnesses that, in reality, require much more granular examination. Precision medicine revolution builds on the fact that diseases look very differently on a molecular level. Two patients may have the same illness, but as their genes, physical characteristics, lifestyles, and environment differ greatly, they may require entirely different treatments. Precision medicine revolutions champions a thoroughly tailored genetic approach to treat millions of patients with genetic diseases.

Heart disease is the number one cause of death in the US with 614,348 cases in 2017 alone. On the other hand, the American Cancer Society estimated about 1.7 million new cancer cases and almost 600,000 deaths in the same year. Many lifestyle factors—weight and diet issues, alcohol and tobacco consumption, among others—contribute to the development of these diseases. However, many individuals are just genetically predisposed to certain diseases.

In addition to health impacts, these diseases also harm the economy. For example, cancer’s economic impact is around $80 billion per year in terms of loss of productivity, wages, and caregiver needs. Alzheimer’s and other forms of dementia cost the US approximately $259 billion in 2017. These costs may drive up to $1.1 trillion by 2050.

Ultimately innovations in precision medicine revolution are expected to substantially improve individuals’ and society’s health as a whole. Cancer, diabetes, heart, and respiratory diseases, as well as Alzheimer’s, could potentially be diminished. The scientific community aims to save and prolong lives using existing health records, genetic testing, data analytics, and supercomputing.

Steps Beyond Conventional Treatments

Precision Medicine Revolution Infographic

Unlocking the molecular characteristics of an individual’s genetics impacts their likelihood of developing or surviving particular conditions. What sets precision medicine apart from current treatment conventions is the degree of reliance on and involvement of genomic data. Granular data helps physicians make highly specific decisions on treatment plans that may essentially be more effective for patients.

Insights gleaned from harnessing genomic data are nothing short of revolutionary, even in its infancy. As focus intensifies on precision medicine revolution, genetic testing is becoming cheaper. Allowing researchers to collect large volumes of data from diverse patient groups. Consequently, clinical, pharmaceutical, and socioeconomic data, and the application of analytics, help researchers observe patterns in the effectiveness of particular treatments.

Clinical trials can then test and validate hypotheses. And if the results are positive, these will support guidelines, practices, and treatments for specific conditions.

Precision medicine is not the same as “personalized medicine”, nor does it exist. Personalized medicine suggests that completely individualized treatments are available for every patient.

This misnomer fell out of fashion, however, when former US President Barack Obama introduced the National Precision Medicine Initiative in 2015.

The Precision Medicine Revolution Initiative

Obama’s State of the Union Address in 2015 first mentioned PMI. Bipartisan support spurred the project, involving the public and private sectors, and everyday patients to share their data and participate in clinical trials.

The PMI Cohort is at the heart of PMI. This group is now calling itself the All of Us Research Program. The program’s goal is to recruit one million Americans to participate, providing researchers volumes of data to fuel their work.

Focus on Cancer

Similar to the initiatives of PMI, former US Vice President Joe Biden oversaw the launch of Cancer Moonshot in 2016. It aims to use the vast source of healthcare data to find vaccine-based immunotherapies against cancer. Like PMI, it also relies on public and private organizations to research and develop new viable treatments.

More initiatives and companies are traversing the same path as PMI and Cancer Moonshot. Promising drugs are being developed that can treat different tumor types, including lung cancer, melanoma, breast cancer, colorectal cancer, and ovarian cancer. Non-invasive screening test kits to detect cancer are even available for order online. With the rapid developments in Precision Medicine revolution, medical treatments and solutions may be ready for consumers in the next handful of years.

 

Ed Kopko, CEO and Publisher of Bold Business

      
Edward Kopko
CEO & Publisher
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Ed Kopko is BoldBusiness.com’s CEO and Publisher. He has a passion for business, economics and media. A serial entrepreneur, Ed has launched Bold Business to help broadcast the great accomplishments that come from business and entrepreneurial activity. He believes the very real and amazing Bold Impacts that these activities have created also make a micro economic case for trade and commerce. Ed’s previous media experience was as CEO, Publisher and Owner of Chief Executive Magazine and its related media activities. He has been published in many media venues including the Wall St. Journal, Detroit Free Press and Forbes.com. He has also been a sought after commentator and appeared numerous times on CNBC, MSNBC, Fox News and other media outlets.

A $2B Project is Bringing in 10,000 Construction Jobs. Find Out Where!

Makeovers are not only applicable to people. The process of redevelopment or restoration are also done on structures like houses, office buildings and schools. Now, reports say that a momentous redevelopment project is on the way. It is going to take place in one of the most historic piers in San Francisco.

Critics mention that the said renovation will not only provide jobs, it will also create a bold impact on the fourth most populous city in California.

Infrastructure developers such as the Forest City Realty Trust Incorporated has innovative plans for California. The real estate company has been eyeing to redevelop Pier 70 for almost 10 years. The Forest City has recently received good news. They were able to launch works for revamping the famous waterfront in San Francisco.

Jack Sylvan is the Senior Vice President of the Forest City. He said, “Along the waterfront, imagine people dining at restaurants and bars, and a cultural arts building that opens up to an expansive lawn where residents are enjoying a concert. Meanwhile, people lounge on oversized porch swings taking in views of the Bay Bridge and downtown San Francisco.”

Works for the historic waterfront will require an estimated amount of $2 billion. The project will also go through three phases and will take 15 to 20 years to finish. Moreover, it will create more than 10,000 construction jobs.

The futuristic plans for Pier 70 will include 1,100 to 2,150 residential units, nine acres of open space and new parks. It will also have 900,000 to 1.75 million square feet of commercial space and 90,000 square feet artist studio space. In addition, Pier 70 will have broad transportation management program and 12,000 employees.

The project also aims to restore three famous structures in Pier 70 including Building 12. Forest City will try to bring back the elegance of the said structure. The Port of San Francisco will assist the Forest City in the revamping project.

As the Executive Director of the Port of San Francisco, Elaine Forbes believes so much in the project. According to her, “This project will provide long-term value for the city and its residents.”

A Glimpse of What Is To Come

There will be no redevelopment without  a new design plan. However, when it comes to Pier 70, James Corner, Field Operations got it all covered. Reports suggested that the new waterfront parks have state-of-the-art designs.

The new Pier 70 will have many open spaces. It is going to feature various public arts from large steel frames to meadow plantings. The construction design will play a vital role not just in the park’s aesthetic but to people’s safety as well.

Because the pier is near the shoreline, James Corner Field Operations made sure that the structure would have protections against potential water rise. They planned to raise the grade of Pier 70 and elevate Building 12.

There is still no official date for the completion of Phase 1. However, officials did say that they expect the first stage of work to finish in 2021 or 2022.

Pier 70 may be a historic waterfront but it already needs a total makeover. Forest City and all its project partners are making sure that they do an exemplary job. They want to modernize and innovate the pier but at the same time, preserve its historic elements.

Creating Infrastructure That Powers Innovation

May 1, 1893. President Grover Cleveland flipped a switch, and under the dazzling glow of 160 thousand light bulbs, the World Columbian Exposition was officially opened. The World Columbian Exposition was often referred to as the “Fair that Changed America.” Also known as the Chicago World Fair, this was the event that gave birth to the future. The modern world will not be the same without the groundbreaking innovations presented in this fair. It introduced some of the quintessential American items such as Wrigley’s Juicy Fruit, Cracker Jack, the zipper, the dishwasher, the moving walkway, and the Ferris wheel.

The most significant innovation presented in this fair was Nikola Tesla’s alternating current. At the height of the so-called “War of Currents” Tesla’s innovation, financially backed by Pittsburg industrialist George Westinghouse, has helped accelerate human progress.

The years between 1860 and early 1900s were marked by unprecedented industrial and technological developments. Innovations that had significant impact on human lives were discovered in this era. This period gave us the automobile, airplane, television and radio, photography, and computer. This list goes on. The world was at the heart of frenzied technological revolution. This was because of the great demand for technologies that could help improve the quality of people’s lives. Moreover, inventors were able to gain support from various institutions for their bold ideas and technological breakthroughs.

Disruption in the 21st Century

Innovation in the 21st century has taken a different form. It has been overturning a lot of conventions and goes by its new name—disruption. The world has been trying to keep up with disruptive forces such as the Internet of Things, Cloud, Mobility, Automation, Big Data, and Artificial Intelligence. Not to mention the challenges of the modern world such as the shifting political and societal landscape, and environmental changes. The challenge to our society is to create an environment that supports and allows technological advancement while confronting these forces.

How to Create an Ecosystem That Supports Innovation

Disruptions turn traditional business models upside down. The need for a more resilient and more efficient innovation infrastructure has become more crucial. Cities and communities must create ecosystems that supports innovation.

  1. First is to create a network. Cities and communities must create a platform where innovators can meet investors; apprentice can find mentors; companies to touch base with experts and consultants. A growing number of cities across the country are following this concept. Tampa Bay Region in Florida is a great example. Through Synapse, the city has been creating opportunities for startups and new entrepreneurs to introduce the next innovation.
  2. Make the network dynamic and responsive. Creating a venue where players in the innovation game can meet is just the first step. The next step is to make these networks responsive to the needs of the community. There has to be a mechanism where innovators can reach out to each other and share experiences. Best practices should easily spread and diffuse across the community.
  3. Allow innovations to thrive. Startups and new businesses are often at the mercy of market response. Cities and communities must create a system for fast and early innovation adoption. Educating the market is vital because commitment to a product or service stems from a compelling value proposition.

The progressive development of the humankind is dependent on innovation. We are making ourselves ready for the future when we create infrastructures that support innovation. But disruptions are definitely going to touch us. The question now is when and up to what degree. Let the innovators innovate. This is the only way to be ready.

The Bold Impacts and Future of Precision Medicine

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